Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma is an aggressive cancer type with one of the lowest survival rates due to late diagnosis and the absence of effective treatments. A better understanding of PDAC biology will help researchers to discover the Achilles' heel of cancer cells. In that regard, our research team investigated the function of an emerging oncoprotein known as myoferlin. Myoferlin is overexpressed in PDAC and its silencing/targeting has been shown to affect cancer cell proliferation, migration, mitochondrial dynamics and metabolism. Nevertheless, our comprehension of myoferlin functions in cells remains limited. In this study, we aimed to understand the molecular mechanism linking myoferlin silencing to mitochondrial dynamics.

Methods

Experiments were perform

SUBMITTER: Anania S 

PROVIDER: S-EPMC10874564 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature