Exercise-Related Physical Activity Relates to Brain Volumes in 10,125 Individuals.

ABSTRACT:

Background

The potential neuroprotective effects of regular physical activity on brain structure are unclear, despite links between activity and reduced dementia risk.

Objective

To investigate the relationships between regular moderate to vigorous physical activity and quantified brain volumes on magnetic resonance neuroimaging.

Methods

A total of 10,125 healthy participants underwent whole-body MRI scans, with brain sequences including isotropic MP-RAGE. Three deep learning models analyzed axial, sagittal, and coronal views from the scans. Moderate to vigorous physical activity, defined by activities increasing respiration and pulse rate for at least 10 continuous minutes, was modeled with brain volumes via partial correlations. Analyses adjusted for age, sex, and to

SUBMITTER: Raji CA 

PROVIDER: S-EPMC10874612 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature