Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses.

ABSTRACT:

Background

Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain.

Methods

We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and individual subtypes of CRC (microsatellite instability [MSI] status, CpG island methylator phenotype [CIMP] status, BRAF and KRAS mutations). Summary data on tumour markers were obtained from two genetic consortia (CCFR, GECCO).

Findings

A 1-standard deviation (SD:5.1 kg/m²) increment in BMI levels was found to increase risks of Jass type 1_MSI-high,C

SUBMITTER: Papadimitriou N 

PROVIDER: S-EPMC10874711 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature