Low-intensity exercise training improves systolic function of heart during metastatic melanoma-induced cachexia in mice.

ABSTRACT: Cardiac dysfunction frequently emerges in the initial stages of cancer cachexia, posing a significant complication of the disease. Physical fitness is commonly recommended in these early stages of cancer cachexia due to its beneficial impacts on various aspects of the condition, including cardiac dysfunction. However, the direct functional impacts of exercise on the heart during cancer cachexia largely remain unexplored. In this study, we induced cancer cachexia in mice using a metastatic B16F10 melanoma model. Concurrently, these mice underwent a low-intensity exercise regimen to investigate its potential role in cardiac function during cachexia. Our findings indicate that exercise training can help prevent metastatic melanoma-induced muscle loss without significant alterations to body an

SUBMITTER: Wang L 

PROVIDER: S-EPMC10874746 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature