The impact of child-specific characteristics on warfarin dosing requirements.

ABSTRACT:

Background

The influence of child characteristics on warfarin dosing has been reported; however, there is no consensus on the nature and extent of this effect.

Objectives

To investigate the impacts of the demographic and clinical characteristics of children on the warfarin dose required to achieve a therapeutic international normalization ratio (INR).

Methods

This retrospective cohort study included children aged 3 months to 14 years old who were prescribed warfarin for 3 months or longer with a "stable INR." The primary outcome was the total daily dose (TDD) and total weekly dose of warfarin required to achieve a therapeutic INR target.

Results

We included 127 patients with a mean age of 7.7 ± 3.7 years and a median weight of 22 (IQR, 16-33) kg. Of the sample,

SUBMITTER: Alakeel YS 

PROVIDER: S-EPMC10874749 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature