Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model.

ABSTRACT:

Objective

This study aimed to investigate the therapeutic effects of Xiaoyao San (XYS), a herbal medicine formula, on exercise capacity and liver mitochondrial metabolomics in a rat model of depression induced by chronic unpredictable mild stress (CUMS).

Methods

A total of 24 male SD rats were randomly divided into four groups: control group (C), CUMS control group (M), Venlafaxine positive treatment group (V), and XYS treatment group (X). Depressive behaviour and exercise capacity of rats were assessed by body weight, sugar-water preference test, open field test, pole test, and rotarod test. The liver mitochondria metabolomics were analyzed by using liquid chromatography-mass spectrometry (LC-MS) method. TCMSP database and GeneCards database were used to screen XYS for pote

SUBMITTER: Zhao W 

PROVIDER: S-EPMC10874765 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature