Deciphering the differential impact of thrombopoietin/MPL signaling on hematopoietic stem/progenitor cell function in bone marrow and spleen.

ABSTRACT: Thrombopoietin (TPO) and its receptor MPL play crucial roles in hematopoietic stem cell (HSC) function and platelet production. However, the precise effects of TPO/MPL signaling on HSC regulation in different hematopoietic niches remain unclear. Here, we investigated the effects of TPO/MPL ablation on marrow and splenic hematopoiesis in TPO^-/- and MPL^-/- mice during aging. Despite severe thrombocytopenia, TPO^-/- and MPL^-/- mice did not develop marrow failure during a 2-year follow-up. Marrow and splenic HSCs exhibited different responses to TPO/MPL ablation and exogenous TPO treatment. Splenic niche cells compensated for marrow HSC loss in TPO^-/- and MPL^-/- mice by upregulating CXCL12 levels. These findings provide new insig

SUBMITTER: Lee S 

PROVIDER: S-EPMC10874852 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature