Body composition changes during breast cancer preventive treatment with anastrozole: Findings from the IBIS-II trial.

ABSTRACT:

Background

Uptake to anastrozole for breast cancer prevention is low, partly due to women's concerns about side effects including gains in weight and specifically gains in body fat. Previous evidence does not link anastrozole with gains in weight, but there is a lack of data on any effects on body composition i.e. changes in fat and fat free mass. Here we assess association of anastrozole with body composition changes in a prospective sub-study from the second international breast intervention trial (IBIS-II).

Methods

Participants had DXA scans at baseline and for five years of anastrozole/placebo and beyond (between March 2004 and September 2017. Primary outcomes were changes in body weight, body fat and fat free mass at 9-18 months. A linear model was used to estimate the

SUBMITTER: Pegington M 

PROVIDER: S-EPMC10874867 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature