Associations between gut microbiota and three prostate diseases: a bidirectional two-sample Mendelian randomization study.

ABSTRACT: According to previous observational researches and clinical trials, the gut microbiota is related to prostate diseases. However, the potential association between gut microbiota and prostate disorders is still uncertain. We first identified groups of gut microbiota based on the phylum, class, order, family, and genus levels from consortium MiBioGen. And we acquired prostate diseases statistics from the FINNGEN study and PRACTICAL consortium. Next, two-sample Mendelian randomization was used to investigate the potential associations between three prevalent prostate disease and gut microbiota. In addition, we performed a reverse MR analysis and Benjamini-Hochberg (BH) test for further research. We investigated the connection between 196 gut microbiota and three prevalent prostate diseases. W

SUBMITTER: Liu X 

PROVIDER: S-EPMC10874943 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature