PRX1-positive mesenchymal stem cells drive molar morphogenesis.

ABSTRACT: Mammalian teeth, developing inseparable from epithelial-mesenchymal interaction, come in many shapes and the key factors governing tooth morphology deserve to be answered. By merging single-cell RNA sequencing analysis with lineage tracing models, we have unearthed a captivating correlation between the contrasting morphology of mouse molars and the specific presence of PRX1⁺ cells within M1. These PRX1⁺ cells assume a profound responsibility in shaping tooth morphology through a remarkable divergence in dental mesenchymal cell proliferation. Deeper into the mechanisms, we have discovered that Wnt5a, bestowed by mesenchymal PRX1⁺ cells, stimulates mesenchymal cell proliferation while orchestrating molar morphogenesis through WNT signaling pathway. The loss o

SUBMITTER: Xu X 

PROVIDER: S-EPMC10874978 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature