Hypothyroidism is a causal determinant of age-related cataract risk in European population: a Mendelian randomization study.

ABSTRACT:

Objective

To determine whether there is a causal relationship between thyroid dysfunction and the risk of age-related cataract (ARC) in the European population.

Design

A two-sample Mendelian randomization (MR) study.

Methods

Hypothyroidism, hyperthyroidism, free thyroxine (fT4), and thyrotropin (TSH) were selected as exposures. The single nucleotide polymorphisms (SNP) of hypothyroidism and hyperthyroidism were obtained from the genome-wide association studies (GWAS) of the IEU database, including 337,159 subjects. Data for fT4 and TSH (72,167 subjects) were extracted from the ThyroidOmics Consortium. ARC was used as the outcome. The SNPs associated with ARC were selected from a GWAS of 216,362 individuals in the FinnGen database. The main method used was the inverse

SUBMITTER: Liu S 

PROVIDER: S-EPMC10874999 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature