Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer.

ABSTRACT:

Background

Colon cancer is a heterogeneous disease and consists of various molecular subtypes. Despite advances in high-throughput expression profiling, limitations remain in predicting clinical outcome and assigning specific treatment to individual cases. Tumor-immune interactions play a critical role, with tumors that activate the immune system having better outcome for the patient. The localization of T cells within tumor epithelium, to enable direct contact, is essential for antitumor function, but bulk DNA/RNA sequencing data lacks spatial distribution information. In this study, we provide spatial T cell tumor distribution and connect these data with previously determined genomic data in the AC-ICAM colon cancer patient cohort.

Methods

Colon cancer patients (n=90) with

SUBMITTER: Zhu H 

PROVIDER: S-EPMC10875018 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature