Airway epithelial cell tolerance to Pseudomonas aeruginosa.

ABSTRACT:

Background

The respiratory tract epithelium is a critical environmental interface that regulates inflammation. In chronic infectious airway diseases, pathogens may permanently colonize normally sterile luminal environments. Host-pathogen interactions determine the intensity of inflammation and thus, rates of tissue injury. Although many cells become refractory to stimulation by pathogen products, it is unknown whether the airway epithelium becomes either tolerant or hypersensitive in the setting of chronic infection. Our goals were to characterize the response of well-differentiated primary human tracheobronchial epithelial cells to Pseudomonas aeruginosa, to understand whether repeated exposure induced tolerance and, if so, to explore the mechanism(s).

Methods

The apical su

SUBMITTER: Wu Q 

PROVIDER: S-EPMC1087506 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature