In vitro co-culture models for the assessment of orthopedic antibacterial biomaterials.

ABSTRACT: The antibacterial biofunctionality of bone implants is essential for the prevention and treatment of implant-associated infections (IAI). In vitro co-culture models are utilized to assess this and study bacteria-host cell interactions at the implant interface, aiding our understanding of biomaterial and the immune response against IAI without impeding the peri-implant bone tissue regeneration. This paper reviews existing co-culture models together with their characteristics, results, and clinical relevance. A total of 36 studies were found involving in vitro co-culture models between bacteria and osteogenic or immune cells at the interface with orthopedic antibacterial biomaterials. Most studies (∼67%) involved co-culture models of osteogenic cells and bacteria (osteo-bac<

SUBMITTER: Eijkel BIM 

PROVIDER: S-EPMC10875071 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature