Unraveling the mystery: a Mendelian randomized exploration of gut microbiota and different types of obesity.

ABSTRACT:

Background

Numerous studies have demonstrated the influence of gut microbiota on the development of obesity. In this study, we utilized Mendelian randomization (MR) analysis to investigate the gut microbiota characteristics among different types of obese patients, aiming to elucidate the underlying mechanisms and provide novel insights for obesity treatment.

Methods

Two-sample multivariable Mendelian randomization (MR) analysis was employed to assess causal relationships between gut microbiota and various obesity subtypes. Gut microbiota data were obtained from the international consortium MiBioGen, and data on obese individuals were sourced from the Finnish National Biobank FinnGen. Eligible single-nucleotide polymorphisms (SNPs) were selected as instrumental variables. Var

SUBMITTER: Liu S 

PROVIDER: S-EPMC10875079 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature