Effects of menstrual disorders and dysmenorrhea on cardiovascular disease: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have demonstrated associations between menstrual disorders, dysmenorrhea, and cardiovascular disease (CVD). However, it remains unclear whether these associations are causal. This study is to investigate whether menstrual disorders and dysmenorrhea causally affect the risk of CVD.

Methods

The summary data for menstrual disorders (excessive menstruation and irregular menses) and dysmenorrhea were obtained from FinnGen study, summary data for CVD were obtained from UK Biobank and meta-analysis. The inverse-variance-weighted method was mainly used in the Mendelian randomization for causality analysis. Sensitivity analyses were performed by several methods under different model assumptions.

Results

Genetic liability to excessive menstruati

SUBMITTER: Lai S 

PROVIDER: S-EPMC10875084 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature