Long-term effects of myo-inositol on traumatic brain injury: Epigenomic and transcriptomic studies.

ABSTRACT:

Background and purpose

Traumatic brain injury (TBI) and its consequences remain great challenges for neurology. Consequences of TBI are associated with various alterations in the brain but little is known about long-term changes of epigenetic DNA methylation patterns. Moreover, nothing is known about potential treatments that can alter these epigenetic changes in beneficial ways. Therefore, we have examined myo-inositol (MI), which has positive effects on several pathological conditions.

Methods

TBI was induced in mice by controlled cortical impact (CCI). One group of CCI animals received saline injections for two months (TBI+SAL), another CCI group received MI treatment (TBI+MI) for the same period and one group served as a sham-operated control. Mice were sacrificed 4 mont

SUBMITTER: Oganezovi N 

PROVIDER: S-EPMC10875114 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature