Unknown

Dataset Information

0

Function and mechanism of bispecific antibodies targeting SARS-CoV-2.

ABSTRACT: As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. This review extensively assesses a spectrum of representative bispecific antibodies targeting SARS-CoV-2, delving into their characteristics, design formats, mechanisms of action, and associated advantages and limitations. The analysis encompasses factors influencing the selection of parental antibodies and strategies for incorporating added benefits in bispecific antibody design. Furthermore, how different classes of parental antibodies contribute to augmenting the broad-spectrum neutralization capability within bispecific antibodies is discussed. In summary, this review presents analyses and discussions aimed at offering valuable insights for shaping future strategies in bispecific antibody design to effectively confront the challenges posed by SARS-CoV-2 and propel advancements in antiviral therapeutic development.

SUBMITTER: Li Z 

PROVIDER: S-EPMC10875118 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Function and mechanism of bispecific antibodies targeting SARS-CoV-2.

Li Zhaohui Z   Zhang Zengyuan Z   Rosen Steven T ST   Feng Mingye M  

Cell insight 20240203 2

As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. This review extensively assesses a spectrum of representative bispecific antibodies targeting SARS-CoV-2, delving into their characteristics, design formats, mechanisms of action, and associated advantages and limitations. The analysis encompasses fact  ...[more]

Similar Datasets

Unknown Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants.
| S-EPMC8020967 | biostudies-literature
Unknown Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern.
| S-EPMC8651051 | biostudies-literature
Unknown Structures from "Engineering Neutralizing SARS-CoV Antibodies to Bind SARS-CoV-2"
| S-BSST379 | biostudies-other
Unknown Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages.
| S-EPMC10387464 | biostudies-literature
Unknown Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages.
| S-EPMC9387138 | biostudies-literature
Unknown Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2.
| S-EPMC7939556 | biostudies-literature
Unknown Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD.
| S-EPMC8498651 | biostudies-literature
Unknown Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies.
| S-EPMC10946335 | biostudies-literature
Transcriptomics Development, Cryo-EM structure and function of potent monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and variant B.1.351
2022-01-11 | GSE174635 | GEO
Other Profiling of human monoclonal antibodies targeting SARS-CoV-2 Omicron variant
2022-07-01 | GSE203030 | GEO