Genetic susceptibility and causal pathway analysis of eye disorders coexisting in multiple sclerosis.

ABSTRACT:

Introduction

The comorbidity of optic neuritis with multiple sclerosis has been well recognized. However, the causal association between multiple sclerosis and optic neuritis, as well as other eye disorders, remains incompletely understood. To address these gaps, we investigated the genetically relationship between multiple sclerosis and eye disorders, and explored potential drugs.

Methods

In order to elucidate the genetic susceptibility and causal links between multiple sclerosis and eye disorders, we performed two-sample Mendelian randomization analyses to examine the causality between multiple sclerosis and eye disorders. Additionally, causal single-nucleotide polymorphisms were annotated and searched for expression quantitative trait loci data. Pathway enrichment analysi

SUBMITTER: Qiu X 

PROVIDER: S-EPMC10875133 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature