Prognostic iron-metabolism signature robustly stratifies single-cell characteristics of hepatocellular carcinoma.

ABSTRACT: Cancer immunotherapy has shown to be a promising method in treating hepatocellular carcinoma (HCC), but suboptimal responses in patients are attributed to cellular and molecular heterogeneity. Iron metabolism-related genes (IRGs) are important in maintaining immune system homeostasis and have the potential to help develop new strategies for HCC treatment. Herein, we constructed and validated the iron-metabolism gene prognostic index (IPX) using univariate Cox proportional hazards regression and LASSO Cox regression analysis, successfully categorizing HCC patients into two groups with distinct survival risks. Then, we performed single-sample gene set enrichment analysis, weighted correlation network analysis, gene ontology enrichment analysis, cellular lineage analysis, and SCENIC analysis

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC10875160 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature