Identification of novel membrane markers in circulating tumor cells of mesenchymal state in breast cancer.

ABSTRACT: Cancer metastasis is a major cause of cancer-related deaths worldwide. The ability to detect and monitor circulating tumor cells (CTCs) offers a promising approach to early detection and management of metastasis. Although studies on epithelial markers for CTC detection are actively underway, the discovery of mesenchymal markers has not been studied sufficiently. In this study, we developed a new pipeline to identify membrane markers in CTCs of mesenchymal state in breast cancer based on expression profiles of the 310 CTC samples. From the total CTC samples, only CTC samples in the mesenchymal state were collected by employing hierarchical clustering. In samples belonging to the mesenchymal state, we calculated the correlation coefficients between 1995 membrane genes and ZEB2, which was det

SUBMITTER: Hwang Y 

PROVIDER: S-EPMC10875194 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature