Multi-functional composite dressings with sustained release of MSC-SLP and anti-adhesion property for accelerating wound healing.

ABSTRACT: Exudate management is of significant clinical value for the treatment of acute wound. Various wound dressings have been developed to restore the function of injured tissues and promote wound healing, but proper exploiting the healing factors inside exudate and achieving anti-adhesion wound care remains a challenge. Herein, we present a novel multi-functional composite dressing (MCD) by coupling supernatant lyophilized powder of mesenchymal stem cells (MSC-SLP) with a sandwich-structured wound dressing (SWD). The developed MCDs demonstrated unique unidirectional drainage capability, stable anti-adhesion characteristics, and improved wound healing performance. The designed SWD with both superhydrophobic inner surface and liquid-absorption ability of mid layer enables the dressings exhibit de

SUBMITTER: Duan W 

PROVIDER: S-EPMC10875241 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature