Does sex affect the efficacy of systemic pharmacological treatments of pain in knee osteoarthritis? A systematic review.

ABSTRACT:

Objective

To determine whether sex influences the analgesic efficacy of systemic pharmacological treatment in patients with knee osteoarthritis.

Design

A systematic review, guided by Cochrane methods, sourced studies from Medline, Cochrane Library, Embase, and CINAHL Plus with Full Text as of October 10, 2022. Eligible studies were double-blind RCTs evaluating systemic pharmacological treatments for knee osteoarthritis in adults, with minimum 30-day treatment duration, reporting sex-specific results or mentioning sex subgroup analysis for analgesic efficacy. The risk of bias was assessed using the Cochrane Risk of Bias tool version 2 (RoB 2).

Results

9 studies (5201 participants) met inclusion criteria, analyzing drugs including duloxetine, etoricoxib, tapentadol, nap

SUBMITTER: Espinosa-Salas S 

PROVIDER: S-EPMC10875265 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature