Demethylase FTO inhibits the occurrence and development of triple-negative breast cancer by blocking m ⁶A-dependent miR-17-5p maturation-induced ZBTB4 depletion.

ABSTRACT: Triple-negative breast cancer (TNBC) is a subtype of breast cancer, and its mechanisms of occurrence and development remain unclear. In this study, we aim to investigate the role and molecular mechanisms of the demethylase FTO (fat mass and obesity-associated protein) in TNBC. Through analysis of public databases, we identify that FTO may regulate the maturation of miR-17-5p and subsequently influence the expression of zinc finger and BTB domain-containing protein 4 (ZBTB4), thereby affecting the occurrence and progression of TNBC. We screen for relevant miRNAs and mRNAs from the GEO and TCGA databases and find that the FTO gene may play a crucial role in TNBC. In vitro cell experiments demonstrate that overexpression of FTO can suppress the proliferation, migration, and invasion ab

SUBMITTER: Ni J 

PROVIDER: S-EPMC10875348 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature