Hydrolytic dynamic kinetic resolution of racemic 3-phenyl-2-oxetanone to chiral tropic acid.

ABSTRACT: Tropic acid was synthesized in a good yield and with high enantioselectivity (81% ee) under non-biphasic conditions via the novel hydrolytic dynamic kinetic resolution of racemic 3-phenyl-2-oxetanone (tropic acid β-lactone) in the presence of a chiral quaternary ammonium phase-transfer catalyst and strongly basic anion exchange resin as the hydroxide ion donor.

SUBMITTER: Kawasaki M 

PROVIDER: S-EPMC10875416 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature