Kinetic analysis of cardiac dynamic ¹⁸F-Florbetapir PET in healthy volunteers and amyloidosis patients: A pilot study.

ABSTRACT:

Objectives

This study aimed to explore the potential of full dynamic PET kinetic analysis in assessing amyloid binding and perfusion in the cardiac region using ¹⁸F-Florbetapir PET, establishing a quantitative approach in the clinical assessment of cardiac amyloidosis disease.

Materials & methods

The distribution volume ratios (DVRs) and the relative transport rate constant (R₁), were estimated by a pseudo-simplified reference tissue model (pSRTM2) and pseudo-Logan plot (pLogan plot) with kidney reference for the region of interest-based and voxel-wise-based analyses. The parametric images generated using the pSRTM2 and linear regression with spatially constrained (LRSC) algorithm were then evaluated. Semi-quantitative analyses include standardized upta

SUBMITTER: Wang H 

PROVIDER: S-EPMC10875429 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature