Aberrant characteristics of peripheral blood innate lymphoid cells in COPD, independent of smoking history.

ABSTRACT:

Background

Distinguishing asthma and COPD can pose challenges in clinical practice. Increased group 1 innate lymphoid cells (ILC1s) have been found in the lungs and peripheral blood of COPD patients, while asthma is associated with elevated levels of ILC2s. However, it is unclear whether the inflammatory characteristics of ILC1s and ILC2s differ between COPD and asthma. This study aims to compare peripheral blood ILC subsets and their expression of inflammatory markers in COPD patients, asthma patients and controls.

Methods

The study utilised multi-colour flow cytometry to analyse peripheral blood ILC populations in clinically stable COPD patients (n=38), asthma patients (n=37), and smoking (n=19) and non-smoking (n=16) controls.

Results

Proportions of peripheral bloo

SUBMITTER: van Zelst CM 

PROVIDER: S-EPMC10875467 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature