Age at menarche and risk of ovarian hyperstimulation syndrome in women undergoing IVF/ICSI cycles: a retrospective cohort study.

ABSTRACT:

Objectives

We aimed to explore the association between age at menarche (AAM) and ovarian hyperstimulation syndrome (OHSS) in fresh in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles.

Design

A retrospective cohort study.

Setting

Data were collected from a large obstetrics and gynaecology hospital in Sichuan, China.

Participants

This study included 17 419 eligible women aged ≤40 years who underwent the first IVF/ICSI cycles from January 2015 to December 2021. Women were divided into three groups according to their AAM: ≤12 years (n=5781), 13-14 years (n=9469) and ≥15 years (n=2169).

Results

The means of age at recruitment and AAM were 30.4 years and 13.1 years, respectively. Restricted cubic spline models suggested that early menar

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10875511 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature