Risk-based lung cancer screening in heavy smokers: a benefit-harm and cost-effectiveness modeling study.

ABSTRACT:

Background

Annual screening through low-dose computed tomography (LDCT) is recommended for heavy smokers. However, it is questionable whether all individuals require annual screening given the potential harms of LDCT screening. This study examines the benefit-harm and cost-effectiveness of risk-based screening in heavy smokers and determines the optimal risk threshold for screening and risk-stratified screening intervals.

Methods

We conducted a comparative cost-effectiveness analysis in China, using a cohort-based Markov model which simulated a lung cancer screening cohort of 19,146 heavy smokers aged 50 ~ 74 years old, who had a smoking history of at least 30 pack-years and were either current smokers or had quit for < 15 years. A total of 34 risk-based screening strategies

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10875747 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature