Several first-line anti-hypertensives act on fibrosarcoma progression and PD1ab blockade therapy.

ABSTRACT:

Purpose

Patients are typically diagnosed with both hypertension and fibrosarcoma. Medical oncologists must prescribe suitable anti-hypertensive medications while considering anti-tumor drugs. Recently, immunotherapy has become prominent in cancer treatment. Nonetheless, it is unknown what role anti-hypertensive medications will play in immunotherapy.

Methods

We examined the effects of six first-line anti-hypertensive medications on programmed cell death protein 1 antibody (PD1ab) in tumor treatment using a mouse model of subcutaneous fibrosarcoma. The drugs examined were verapamil, losartan, furosemide, spironolactone, captopril, and hydrochlorothiazide (HCTZ). The infiltration of CD8⁺ T cells was examined by immunohistochemistry. Additionally, several in vitro an

SUBMITTER: Sun J 

PROVIDER: S-EPMC10875773 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature