C-Myc protein expression indicates unfavorable clinical outcome in surgically resected small cell lung cancer.

ABSTRACT:

Background

By being highly involved in the tumor evolution and disease progression of small cell lung cancer (SCLC), Myc family members (C-Myc, L-Myc, and N-Myc) might represent promising targetable molecules. Our aim was to investigate the expression pattern and prognostic relevance of these oncogenic proteins in an international cohort of surgically resected SCLC tumors.

Methods

Clinicopathological data and surgically resected tissue specimens from 104 SCLC patients were collected from two collaborating European institutes. Tissue sections were stained by immunohistochemistry (IHC) for all three Myc family members and the recently introduced SCLC molecular subtype-markers (ASCL1, NEUROD1, POU2F3, and YAP1).

Results

IHC analysis showed C-Myc, L-Myc, and N-Myc positiv

SUBMITTER: Lang C 

PROVIDER: S-EPMC10875875 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature