Platycodin D2 enhances P21/CyclinA2-mediated senescence of HCC cells by regulating NIX-induced mitophagy.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) cells usually show strong resistance to chemotherapy, which not only reduces the efficacy of chemotherapy but also increases the side effects. Regulation of autophagy plays an important role in tumor treatment. Cell senescence is also an important anti-cancer mechanism, which has become an important target for tumor treatment. Therefore, it is of great clinical significance to find anti-HCC drugs that act through this new mechanism. Platycodin D2 (PD2) is a new saponin compound extracted from the traditional Chinese medicine Platycodon grandiflorum.

Purpose

Our study aimed to explore the effects of PD2 on HCC and identify the underlying mechanisms.

Methods

First, the CCK8 assay was used to detect the inhibitory effect of PD2 o

SUBMITTER: Sun L 

PROVIDER: S-EPMC10875888 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature