Protein N-glycosylation in the bronchoalveolar space differs between never-smokers and long-term smokers with and without COPD.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) kills millions of people annually and patients suffering from exacerbations of this disorder display high morbidity and mortality. The clinical course of COPD is associated with dysbiosis and infections, but the underlying mechanisms are poorly understood. Glycosylation of proteins play roles in regulating interactions between microbes and immune cells, and knowledge on airway glycans therefore contribute to the understanding of infections. Furthermore, glycans have biomarker potential for identifying smokers with enhanced risk for developing COPD as well as COPD subgroups. Here, we characterized the N-glycosylation in the lower airways of healthy never-smokers (HNS, n = 5) and long-term smokers (LTS) with (LTS+, n = 4) and without COPD (LTS-, n

SUBMITTER: Venkatakrishnan V 

PROVIDER: S-EPMC10876041 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature