Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.

ABSTRACT: The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY_1-36), but not endocrine PYY_3-36, acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it displays selective antifungal activity against virulent Candida albicans hyphae-but not the yeast form. PC-PYY is a cationic molecule that interacts with the anionic surfaces of fungal hyphae to cause membrane disruption and transcriptional reprogramming that selects for t

SUBMITTER: Pierre JF 

PROVIDER: S-EPMC10876062 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature