A systematic review of genetic variation within nicotinic acetylcholine receptor genes and cigarette smoking cessation.

ABSTRACT:

Background

Nicotine produces its effects by binding to nicotinic acetylcholine receptors (nAChRs). Variants of genes encoding properties of nAChRs are candidates for affecting likelihood of smoking cessation.

Methods

A systematic review was conducted summarizing evidence of associations between single nucleotide polymorphisms (SNPs) of nAChR genes and smoking cessation. From 24 articles meeting inclusion criteria, summary odds ratios (ORs) for associations between nine SNPs and smoking cessation were calculated from 26 studies (N = 233-29,072) stratified by gene, ancestry, study design, and pharmacotherapy; SNPs in linkage disequilibrium were pooled. Results for a tenth SNP from two GWAS were summarized.

Results

People of European ancestry with minor alleles of CHRNA5

SUBMITTER: Jones SK 

PROVIDER: S-EPMC10876157 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature