Hypertension and NAFLD risk: Insights from the NHANES 2017-2018 and Mendelian randomization analyses.

ABSTRACT:

Background

Hypertension and non-alcoholic fatty liver disease (NAFLD) share several pathophysiologic risk factors, and the exact relationship between the two remains unclear. Our study aims to provide evidence concerning the relationship between hypertension and NAFLD by analyzing data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 and Mendelian randomization (MR) analyses.

Methods

Weighted multivariable-adjusted logistic regression was applied to assess the relationship between hypertension and NAFLD risk by using data from the NHANES 2017-2018. Subsequently, a two-sample MR study was performed using the genome-wide association study (GWAS) summary statistics to identify the causal association between hypertension, systolic blood pressure (SBP)

SUBMITTER: Yuan M 

PROVIDER: S-EPMC10876227 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature