Discovery of plasma proteome markers associated with clinical outcome and immunological stress after cardiac surgery.

ABSTRACT:

Background

Molecular mechanisms underlying perioperative acute phase reactions in cardiac surgery are largely unknown. We aimed to characterise perioperative alterations of the acute phase plasma proteome in a cohort of adult patients undergoing on-pump cardiac surgery using high-throughput mass spectrometry and to identify candidate proteins potentially relevant to postoperative clinical outcome through a novel, multi-step approach.

Methods

This study is an analysis of the Bern Perioperative Biobank, a prospective cohort of adults who underwent cardiac surgery with the use of cardiopulmonary bypass (CPB) at Bern University Hospital between January and December 2019. Blood samples were taken before induction of anaesthesia and on postoperative day one. Proteomic analyses wer

SUBMITTER: Bello C 

PROVIDER: S-EPMC10876477 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature