Converging survival trends in non-small cell lung cancer patients with and without brain metastasis receiving state-of-the-art treatment.

ABSTRACT:

Introduction

Historically, patients with brain metastasis (BM) have been excluded from clinical trials investigating treatments for non-small cell lung cancer (NSCLC) due to their unfavorable prognosis. Advanced treatments have increased survival prospects for NSCLC patients with BM. This study evaluated the life expectancy of NSCLC patients with and without BM in the context of contemporary treatments.

Methods

Outcome data were collected for patients with advanced NSCLC attending a tertiary medical center between 2015 and 2020. Patients were stratified according to BM status and compared for overall survival (OS) using log-rank and Cox regression analyses.

Results

The cohort included 360 patients with NSCLC of whom 134 (37.2%) had BM. Most (95%) of cases of BM develo

SUBMITTER: Averbuch I 

PROVIDER: S-EPMC10876498 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature