Quantitative calibration of Tb-161 SPECT/CT in view of personalised dosimetry assessment studies.

ABSTRACT:

Background

Terbium-161 (¹⁶¹Tb)-based radionuclide therapy poses an alternative to current Lutetium-177 (¹⁷⁷Lu) approaches with the additional benefit of secondary Auger and conversion electron emissions capable of delivering high doses of localised damage to micro-metastases including single cells. Quantitative single-photon emission computed tomography, paired with computed tomography (SPECT/CT), enables quantitative measurement from post-therapy imaging. In view of dosimetry extrapolations, a Tb-161 sensitivity SPECT/CT camera calibration was performed using a method previously validated for ¹⁷⁷Lu.

Methods

Serial imaging of a NEMA/IEC body phantom with Tb-161 was performed on SPECT/CT with low-energy high-resolution collimators employing a

SUBMITTER: McIntosh L 

PROVIDER: S-EPMC10876500 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature