Chelator impact: investigating the pharmacokinetic behavior of copper-64 labeled PD-L1 radioligands.

ABSTRACT:

Background

Programmed cell death ligand 1 (PD-L1) plays a critical role in the tumor microenvironment and overexpression in several solid cancers has been reported. This was associated with a downregulation of the local immune response, specifically of T-cells. Immune checkpoint inhibitors showed a potential to break this localized immune paralysis, but only 30% of patients are considered responders. New diagnostic approaches are therefore needed to determine patient eligibility. Small molecule radiotracers targeting PD-L1, may serve as such diagnostic tools, addressing the heterogeneous PD-L1 expression between and within tumor lesions, thus aiding in therapy decisions.

Results

Four biphenyl-based small-molecule PD-L1 ligands were synthesized using a convergent synthetic ro

SUBMITTER: Krutzek F 

PROVIDER: S-EPMC10876507 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature