The ctenophore Mnemiopsis leidyi deploys a rapid injury response dating back to the last common animal ancestor.

ABSTRACT: Regenerative potential is widespread but unevenly distributed across animals. However, our understanding of the molecular mechanisms underlying regenerative processes is limited to a handful of model organisms, restricting robust comparative analyses. Here, we conduct a time course of RNA-seq during whole body regeneration in Mnemiopsis leidyi (Ctenophora) to uncover gene expression changes that correspond with key events during the regenerative timeline of this species. We identified several genes highly enriched in this dataset beginning as early as 10 minutes after surgical bisection including transcription factors in the early timepoints, peptidases in the middle timepoints, and cytoskeletal genes in the later timepoints. We validated the expression of early response transcription fact

SUBMITTER: Mitchell DG 

PROVIDER: S-EPMC10876535 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature