Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge.

ABSTRACT: GrimAge acceleration has previously predicted age-related morbidities and mortality. In the current study, we sought to examine how GrimAge is associated with genetic predisposition for systemic inflammation and whether psychosocial factors moderate this association. Military veterans from the National Health and Resilience in Veterans study, which surveyed a nationally representative sample of European American male veterans, provided saliva samples for genotyping (N = 1135). We derived polygenic risk scores (PRS) from the UK Biobank as markers of genetic predisposition to inflammation. Results revealed that PRS for three inflammatory PRS markers-HDL (lower), apolipoprotein B (lower), and gamma-glutamyl transferase (higher)-were associated with accelerated GrimAge. Additionally, these PRS

SUBMITTER: Tamman AJF 

PROVIDER: S-EPMC10876568 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature