Emerging role of mesenchymal stem cell-derived extracellular vesicles in periodontal regeneration.

ABSTRACT: Periodontitis is a prevalent oral ailment that harms both hard and soft tissues of the periodontium, leading to loosening and eventual removal of the teeth. Current clinical treatments have limitations in achieving complete periodontal tissue regeneration. Mesenchymal stem cells (MSCs) have garnered attention due to their unique characteristics and potential as a promising new therapy for periodontitis. Research suggests that the role of MSCs in regenerative medicine primarily occurs through the paracrine pathway, involving the emission of particles encased by lipids called extracellular vesicles (EVs) abundant in bioactive compounds. These EVs play a vital function in controlling the activities of periodontal tissues and immune system cells, and by influencing the immediate surrounding, t

SUBMITTER: Anvari Y 

PROVIDER: S-EPMC10876597 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature