High-Dose Ionizing Radiation Impairs Healthy Dendrite Growth in C. elegans.

ABSTRACT:

Purpose

The nervous system is vulnerable to radiation damage, and further optimization is required to increase the efficacy of radiation therapy while reducing harm to neurons. Given recent developments in heavy ion therapy, experimental models would be valuable to improve these therapies. We used the nematode Caenorhabditis elegans (C. elegans) to evaluate the effects of high-dose radiation on neuron development.

Methods and materials

In this study, we used confocal microscopy to assess dendritic growth of the PVD nociceptor after high-dose gamma-irradiation from a Cs-137 source.

Results

Irradiation during an early larval stage (L2) delayed overall development but also independently impaired dendrite outgrowth in the PVD nociceptive neuron. Irradiation

SUBMITTER: Freitag R 

PROVIDER: S-EPMC10876608 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature