Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening.

ABSTRACT:

Background

Hereditary factors, including single genetic variants and family history, can be used for targeting colorectal cancer (CRC) screening, but limited data exist on the impact of polygenic risk scores (PRS) on risk-based CRC screening.

Methods

Using longitudinal health and genomics data on 453,733 Finnish individuals including 8801 CRC cases, we estimated the impact of a genome-wide CRC PRS on CRC screening initiation age through population-calibrated incidence estimation over the life course in men and women.

Results

Compared to the cumulative incidence of CRC at age 60 in Finland (the current age for starting screening in Finland), a comparable cumulative incidence was reached 5 and 11 years earlier in persons with high PRS (80-99% and >99%, respectively), wh

SUBMITTER: Tamlander M 

PROVIDER: S-EPMC10876651 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature