Diabetes mellitus increases risk of adverse drug reactions and death in hospitalised older people: the SENATOR trial.

ABSTRACT:

Purpose

Adverse drug reactions (ADRs) are a major cause of morbidity and mortality, especially in older people. Older people with diabetes mellitus may be at especially high risk of ADRs but this risk has not been well studied. This study aimed to compare severity and type of ADRs in hospitalised, multimorbid older people with and without diabetes and secondly to assess the impact of ADRs on mortality, rehospitalisation and length of stay.

Methods

Participants in the SENATOR (Software Engine for the Assessment and optimization of drug and non-drug Therapy in Older peRsons) trial were assessed for 12 common and 'other' prevalent and incident adverse drug reactions using a blinded end-point adjudication process. Descriptive analyses, logistic regression and mediation analyses

SUBMITTER: Chinmayee A 

PROVIDER: S-EPMC10876722 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature