Modified medication use in dysphagia: the effect of thickener on drug bioavailability-a systematic review.

ABSTRACT:

Introduction

Dysphagia is associated with long-term conditions including strokes, dementia, Parkinson's disease and frailty. Dysphagia affects 30-40% of the population aged over 65 years-old. Adults with dysphagia often experience long-term conditions requiring multiple medications (often > 5) to manage these. The thickening of liquids is a common compensatory strategy in dysphagia management. Studies suggest that immersion in thickened liquids affects medicines' solubility in vitro. Clinicians and pharmacists are unaware of the pharmacokinetic/therapeutic effects of thickened liquids on oral medicines. We conducted a systematic review of existing literature on thickeners' effects on drug bioavailability.

Methodology

We performed a literature search of MEDLINE & EMBASE. Sear

SUBMITTER: Atkin J 

PROVIDER: S-EPMC10876765 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature