Henle fiber layer thickening and deficits in objective retinal function in participants with a history of multiple traumatic brain injuries.

ABSTRACT:

Introduction

This study tested whether multiple traumatic brain injuries (TBIs) alter the structure of the Henle fiber layer (HFL) and degrade cell-specific function in the retinas of human participants.

Methods

A cohort of case participants with multiple TBIs and a cohort of pair-matched control participants were prospectively recruited. Directional optical coherence tomography and scanning laser polarimetry measured HFL thickness and phase retardation, respectively. Full-field flash electroretinography (fERG) assessed retinal function under light-adapted (LA) 3.0, LA 30 Hz, dark-adapted (DA) 0.01, DA 3.0, and DA 10 conditions. Retinal imaging and fERG outcomes were averaged between both eyes, and paired t-tests or Wilcoxon signed-rank tests analyzed inter-cohort difference

SUBMITTER: Stern-Green EA 

PROVIDER: S-EPMC10876769 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature