Subject-specific timing adaption in time-encoded arterial spin labeling imaging.

ABSTRACT:

Objectives

One challenge in arterial spin labeling (ASL) is the high variability of arterial transit times (ATT), which causes associated arterial transit delay (ATD) artifacts. In patients with pathological changes, these artifacts occur when post-labeling delay (PLD) and bolus durations are not optimally matched to the subject, resulting in difficult quantification of cerebral blood flow (CBF) and ATT. This is also true for the free lunch approach in Hadamard-encoded pseudocontinuous ASL (H-pCASL).

Material and methods

Five healthy volunteers were scanned with a 3 T MR-system. pCASL-subbolus timing was adjusted individually by the developed adaptive Walsh-ordered pCASL sequence and an automatic feedback algorithm. The quantification results for CBF and ATT and the respecti

SUBMITTER: Breutigam NJ 

PROVIDER: S-EPMC10876770 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature