Quantification of LDL-Cholesterol Corrected for Molar Concentration of Lipoprotein(a).

ABSTRACT:

Purpose

Cholesterol in lipoprotein(a) [Lp(a)-C] is commonly estimated as 30% of the measured Lp(a) mass. However, difficulties in the accurate measurement of Lp(a) mass, along with the inaccuracy of the 30% assumption, produce erroneous values when LDL-C is corrected for Lp(a) [LDL-C_Lp(a)corr]. Our aim was to develop a new formula for LDL-C_Lp(a)corr to reduce this error.

Methods

We developed a new formula to calculate Lp(a)-C from the molar measurement of Lp(a), which is Lp(a) nmol/L × 0.077 = Lp(a)-C mg/dL. The calculated Lp(a)-C is subtracted from LDL-C to obtain LDL-C_Lp(a)corr. The results obtained with our novel formula versus the conventional formula were compared in 440 samples from 239 participants enrolled in the BANTING study.

Res

SUBMITTER: Rosenson RS 

PROVIDER: S-EPMC10876802 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature